Generative AI in Drug Development
Generative AI in Drug Development
What I read in week 6/2023
ChatGPT is taking the world by storm. It has already crossed the 100 Million User mark. It started on November 30, which means — 2 months to this amazing mark.
Reimagining the future of clinical trials
Integrating Artificial Intelligence (AI) into medicine has led to major advancements in various specialties, from radiology to dermatology. However, its integration into clinical trials has needed to be faster due to the perceived competition between AI and human intelligence. But it’s time to embrace AI as a tool to augment human intelligence rather than replace it. The clinical trial guidelines, SPIRIT-AI and CONSORT-AI, aim to standardize and transparently report on AI-powered clinical trials.
AI has the potential to transform every phase of drug development, from drug design to the complete drug development cycle. In clinical trial conduct, AI can help automate rapid processing, track vital signs and patient questionnaires in real time, and even assist with reading scans and medical images.
The next two decades will be crucial in tapping the potential of AI to generate multidimensional evidence. This will involve extracting, collating, and mining vast amounts of data, including natural history data, genomics, published clinical studies, real-world data, and data from wearable smart devices and the Internet of Medical Things. The result will be a new era of deep evidence-based medicine that provides more comprehensive patient care.
In conclusion, AI has the potential to revolutionize healthcare, and it’s time to take advantage of its capabilities to transform clinical trials and evidence-based medicine.
The next generation of evidence-based medicine - Nature Medicine
Caution with AI-generated content in biomedicine
ChatGPT has shown how addictive the use of such a conversational tool is. Instead of getting an answer in the form of the typical 4,000,000 links summary, prioritized by the highest paying company amongst the links, ChatGPT provides one answer in a conversational tone.
It is mesmerizing.
I made fun today by asking a colleague on Linkedin whether ChatGPT has become an Oracle or a Religion in no time.
The thing is, when something feels good, people start trusting it. However, there are also some risk associates.
I started working in the pharma industry in 2006. Before, I did a lot of studies on “healthy lifestyle.” Since a curriculum at the universities didn’t exist, I attended a lot of seminars. All were worthwhile attending, and often the speakers presented results without scientific evidence.
They didn’t have bad intentions or try to present false evidence. It’s just that they didn’t know anything about scientific methods.
The whole pharma industry revolves around two topics: Safety and Efficacy. Only what science proves with detailed studies to be safe and effective reaches the market.
The authorities weed out all other products. However, in “lifestyle seminars,” often, these weeding-out phases don’t happen, so teachers continue presenting ideas without evidence.
In the last twenty years, science has tested many claims — some stood the test of evidence, while others failed.
And yet, when Google became better, guess what I did:
You are right.
Instead of consulting a professional following a solid work ethic, I also fell into the
Ask Dr. Google Self-Medication Trap
And here you go again. Knowing the power of science, I shouldn’t have done what I did - consulting Dr. Google frequently.
Who guarantees that the advice a company pays to get a high rank in google is safe and effective? Nobody. It is not Google’s job.
Google is a link summary and doesn’t need to be certified as a medical device or digital health app. Google never promoted itself as a tool for giving medical advice.
And yet, a 2019 study revealed that 89% of US citizens consulted Dr. Google before engaging with a medical professional.
Now when I ask ChatGPT, I get a warning that it isn’t built to give medical advice but still provides some general information. Open AI has a great work ethic. But will all companies have such a work ethic?
When will regulators demand getting proper certifications?
Alex Zhavoronkov shares his scientific thoughts about this important topic in an article on Nature:
Caution with AI-generated content in biomedicine
Ten commandments for engaging with AI in Biomedicine
This article describes some ideas on beneficially engaging with AI.
It is a reminder that AI isn’t magic and almost always needs a double-check.
This is something I quickly realized with ChatGPT. At first, the Dunning-Kruger Effect fully got me.
Hell yeah. This tool is fantastic. I can now do everything better in 1% of the time it took me.
Then came the realization:
What, wait a minute. That doesn’t sound right. ChatGPT seems to make mistakes.
And the second revelation:
Oh my god. This tool has limited capabilities and repeats itself as quickly as normal human beings.
Now I am at the point where I use the tool to improve my work. It helps with brainstorming, brings in a fresh angle of perspective, or gets my creativity going when I feel a block.
Ten simple rules for engaging with artificial intelligence in biomedicine
Upcoming Conversations and Events:
Check out the Q1 highlight on March 16:
From Blue Collar to Biotech: The Incredible Journey of NanoTemper CEO Philipp Baaske and His Search for Investment Amidst Financial Crisis."
The CEO of Nanotemper, Dr. Philipp Baaske, will join us in Vienna in our Recording Studio to discuss his journey as an entrepreneur.
What challenges did he have to overcome?
Why did he decide to bootstrap his company?
How did he find customers and a business angel to get off the ground?
Join us as we delve into Philipp Baaske's inspiring story of perseverance and determination in founding NanoTemper and the invaluable lessons he learned from his angel investor Volker Hofmann on the road to success. Tune in to hear about the power of belief in your ideas, the importance of support from family and friends, and the impact an angel investor can have on a startup.
Timetable for March 16, 2023
11 am CET - Philipp Baaske - Livestream on Linkedin and Zoom Webinar directly from the Podcasting Studio
3 pm CET - LSG2G Networking Get2gether: Meet Philipp Baaske. The location will be announced in March
February 14, 2023 - 12 pm CET - Alex Zhavoronkov - How to Use Generative AI in Drug Discovery - Article about Alex and his company Insilico Medicine
February 17, 2023 - 7 pm CET - Kimberley Miner - Climate Change
February 24, 2023 - 6 pm CET - DC Palter - To Kill a Unicorn
Meet us at the AngloNordic Conference on April 20, 2023
We are looking for speakers. Do you know interesting experts in these areas?
Longevity, preventive medicine, and well-being;
pharma and health tech;
artificial intelligence;
climate change;
and entrepreneurship and investing.
Send a mail to cs@cslifescienceinvest.com
2 Podcasts from this week:
Investing with Impact: Jeevan Sunner's Story as a Female Venture Capitalist
SP 4: Arnold Schwarzenegger's 6 Rules of Success: A Guide to Living Your Dreams
1 Youtube Takeaway from this week
Books I am reading this week
At this Silicon Valley startup, murder is a feature, not a bug…
SüprDüpr is the hottest startup in Silicon Valley until one of the company’s physicists disappears and hacker Ted Hara sets out to find his missing friend.
Led by a glamorous young scientist and funded by billionaire crypto investors, SüprDüpr promises to revolutionize transportation. But as Ted investigates the secretive company, nothing is what it seems.
Are the millions the company is spending building a homeless shelter truly corporate philanthropy? Or is the company a complex real estate scam? As the homeless residents of San Jose begin disappearing, too, it appears something far more sinister is happening downtown. But why was his friend searching for a pair of elephants before he disappeared?
Days away from the technology unveiling that will confer unimaginable riches on the company’s investors, Ted becomes trapped in a web of corruption protecting its founder. While avoiding the police, he has to find out why people are disappearing before it’s too late.
A crazy ride through the high-tech world of Silicon Valley, To Kill a Unicorn shows how far startup founders are willing to go to build their unicorns.
To Kill a Unicorn
Best Quote from this week
If you want to make everyone happy, don’t be a leader. Sell ice cream. - Steve Jobs
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